Autores
Belén Torres, Francisco Aguilar, Ernesto Franco, Elena Sánchez, Julio Sánchez‐Román, Juan Jiménez Alonso, Antonio Núñez‐Roldán, Javier Martín, María Francisca González‐Escribano
Fecha de publicación
2004/7
Revista
Arthritis & Rheumatism: Official Journal of the American College of Rheumatology
Volumen
50
Número
7
Páginas
2211-2215
Editor
Wiley Subscription Services, Inc., A Wiley Company
Descripción
Objective
To investigate the possible association of the CT60A/G marker with systemic lupus erythematosus (SLE) in Spanish patients, and to identify the possible CTLA4 haplotype responsible for the association, taking into account other polymorphisms described at positions −1722T/C, −319C/T, +49A/G, and the microsatellite (AT)n in the 3′‐untranslated region (3′‐UTR) of the CTLA4 gene.
Methods
Genotyping of CT60 was performed in 395 patients with SLE and 293 healthy controls using polymerase chain reaction (PCR)–restriction fragment length polymorphism analysis. Genotyping of the rest of the dimorphisms has been previously reported. Genotyping of microsatellite polymorphism (AT)n in the 3′‐UTR was performed using PCR with a fluorescence‐labeled primer.
Results
With regard to CT60A/G, the frequency of the AA genotype was significantly decreased among the SLE patients (18.7 …
Citas totales
Artículos de Google Académico
B Torres, F Aguilar, E Franco, E Sánchez… - Arthritis & Rheumatism: Official Journal of the American …, 2004