Authors
Christian Heiss, Sarah Jahn, Melanie Taylor, Wendy May Real, Franca S Angeli, Maelene L Wong, Nicolas Amabile, Megha Prasad, Tienush Rassaf, Javier I Ottaviani, Shirley Mihardja, Carl L Keen, Matthew L Springer, Andrew Boyle, William Grossman, Stanton A Glantz, Hagen Schroeter, Yerem Yeghiazarians
Publication date
2010/7/13
Journal
Journal of the American College of Cardiology
Volume
56
Issue
3
Pages
218-224
Publisher
American College of Cardiology Foundation
Description
Objectives
In patients with coronary artery disease (CAD) medically managed according to currently accepted guidelines, we tested whether a 1-month dietary intervention with flavanol-containing cocoa leads to an improvement of endothelial dysfunction and whether this is associated with an enhanced number and function of circulating angiogenic cells (CACs).
Background
Dietary flavanols can improve endothelial dysfunction. The CACs, also termed endothelial progenitor cells, are critical for vascular repair and maintenance of endothelial function.
Methods
In a randomized, controlled, double-masked, cross-over trial, 16 CAD patients (64 ± 3 years of age) received a dietary high-flavanol intervention (HiFI [375 mg]) and a macronutrient- and micronutrient-matched low-flavanol intervention (LoFI [9 mg]) twice daily in random order over 30 days.
Results
Endothelium-dependent vasomotor function, as measured by flow …
Total citations
Scholar articles
C Heiss, S Jahn, M Taylor, WM Real, FS Angeli… - Journal of the American College of Cardiology, 2010
C Heiss, S Jahn, M Taylor - Improvement of endothelial function with dietary …, 2010