Authors
Arshed A Quyyumi, Edmund K Waller, Jonathan Murrow, Fabio Esteves, James Galt, John Oshinski, Stamatios Lerakis, Salman Sher, Douglas Vaughan, Emerson Perin, James Willerson, Dean Kereiakes, Bernard J Gersh, Douglas Gregory, Astrid Werner, Thomas Moss, Wai Shun Chan, Robert Preti, Andrew L Pecora
Publication date
2011/1/1
Journal
American heart journal
Volume
161
Issue
1
Pages
98-105
Publisher
Mosby
Description
BACKGROUND
The objective of the study was to determine whether the effects of infarct-related artery (IRA) infusion of autologous bone marrow–derived CD34+ cells after ST elevation myocardial infarction (STEMI) are dependent on the dose (quantity and mobility) of the cells infused. Beneficial effects of IRA infusion of mononuclear cells after STEMI have been inconsistent, possibly because of differences in timing, cell type, quantity, and mobility of infused cells.
METHODS
Patients were randomized to bone marrow harvest (n = 16) or control (n = 15). At a median of 8.3 days after coronary stenting for STEMI, CD34+ cells were infused via the IRA at 3 dose levels (5, 10, and 15 × 106) in cohorts of 5 patients each. Baseline and follow-up imaging and ex vivo CD34+ cell mobility were performed.
RESULTS
Cell harvest and infusion were safe. Quantitative rest hypoperfusion score measured by single-photon …
Total citations
Scholar articles
AA Quyyumi, EK Waller, J Murrow, F Esteves, J Galt… - American heart journal, 2011