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Antibacterial resistance has recently been a huge burden on the pharmaceutical industry and a global threat to human’s health. Biofilm formation is a complex group of one or more microorganisms grouped together forming an extracellular polymeric substance (EPS) matrix that restricts the effectivity of antimicrobial compounds causing bacterial resistance infections. The discovery of new antibiofilm agents to serve us in the antibiotic pipeline is in huge demand as an increasing number of pathogenic bacteria are no longer responding to current antibiotics, resulting in less efficient treatment of infections. The marine environment is a novel source of thousands of natural products that possess various biological activities. Marine sponges are optimal sources for unique chemical scaffolding associated with symbiotic interactions. Marine sponges and their symbionts account for about 30% of the compounds discovered …