View article

An undescribed Philippine marine sponge of the genus Strongylophora yielded a new meroditerpenoid−strongylophorine dimer (1) and the known meroditerpenoids, strongylophorine-2 (2), strongylophorine-3 (3), and strongylophorine-4 (4). The structures of the compounds were established on the basis of NMR spectroscopic and mass spectrometric data. The position of the inter-unit linkage in the new compound was elucidated after methylation and 1D ¹H NOE difference experiments. This is the first report wherein theH and ¹³C NMR data of the strongylophorine congeners are fully and unambiguously assigned on the basis of 2D NMR spectroscopy. Compounds 2 and 3 exhibited slight activity against Micrococcus luteus and Salmonella typhii, respectively. Compound 3 was active against the phytopathogenic fungus Cladosporium cucumerinum and also against the neonate larvae of the polyphagous pest …