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Phaeurus antarcticus is a member of the Desmarestiaceae family endemic to the Antarctic Peninsula. Reports addressing its chemical composition and biological activities are scarce. Herein, bioactive non‐polar compounds of P. antarcticus against pathogenic bacteria, Leishmania amazonensis and Neospora caninum parasites were targeted through GC‐MS Molecular Networking and multivariate analysis (OPLS‐DA). The effects on horseradish peroxidase (HRP) were also evaluated. P. antarcticus exhibited selective bacteriostatic and bactericidal activities against Staphylococcus aureus with MIC and MBC values from 6.25–100 μg mL⁻¹. Fractions HX‐FC and HX‐FD were the most active against L. amazonensis with EC₅₀ ranging from 18.5–62.3 μg mL⁻¹. Additionally, fractions HX‐FC and HX‐FD showed potent inhibition of N. caninum at EC₅₀ values of 2.8 and 6.3 μg mL⁻¹, respectively. All …