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Synergistic bimetallic catalysis has become a very efficient tool for the selective carboboration of unsaturated hydrocarbons. This synthetic approach is based on the use of a catalytically generated boron-substituted organocopper nucleophile in a cross-coupling reaction catalyzed by a second transition metal. This way, hydrocarbons can be used as pro-nucleophiles in this type of transformations thus rendering a clean and operationally simple alternative to the traditional cross-coupling methodologies. This review provides a summary of the developments on this topic and discusses both the synthetic utility and mechanisms of these reactions.

1 Introduction

2 Carboboration of Alkenes via Synergistic Catalysis

3 Carboboration of 1,3-Dienes via Synergistic Catalysis

4 Carboboration of Alkynes via Synergistic Catalysis

5 Conclusions