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Uruguay and Chile have the highest levels of marijuana use in Latin America, and have experienced consistent increases during the last two decades. We aim to calculate separate age–period–cohort (APC) effects for past‐year marijuana use in Uruguay and Chile, which have similar epidemiologica, and demographic profiles but diverging paths in cannabis regulation.

APC study in which period and cohort effects were estimated as first derivative deviations from their linear age trend, separately by country and gender.

Uruguay and Chile.

General population between 15 and 64 years.

Past‐year marijuana use from household surveys with five repeated cross‐sections between 2001 and 2018 in Uruguay (median n = 4616) and 13 between 1994 and 2018 in Chile (median n = 15 895).

Marijuana use prevalence in both countries …