Authors
Neil Hall, Marianna Karras, J Dale Raine, Jane M Carlton, Taco WA Kooij, Matthew Berriman, Laurence Florens, Christoph S Janssen, Arnab Pain, Georges K Christophides, Keith James, Kim Rutherford, Barbara Harris, David Harris, Carol Churcher, Michael A Quail, Doug Ormond, Jon Doggett, Holly E Trueman, Jacqui Mendoza, Shelby L Bidwell, Marie-Adele Rajandream, Daniel J Carucci, John R Yates III, Fotis C Kafatos, Chris J Janse, Bart Barrell, C Michael R Turner, Andrew P Waters, Robert E Sinden
Publication date
2005/1/7
Source
Science
Volume
307
Issue
5706
Pages
82-86
Publisher
American Association for the Advancement of Science
Description
Plasmodium berghei and Plasmodium chabaudi are widely used model malaria species. Comparison of their genomes, integrated with proteomic and microarray data, with the genomes of Plasmodium falciparum and Plasmodium yoelii revealed a conserved core of 4500 Plasmodium genes in the central regions of the 14 chromosomes and highlighted genes evolving rapidly because of stage-specific selective pressures. Four strategies for gene expression are apparent during the parasites' life cycle: (i) housekeeping; (ii) host-related; (iii) strategy-specific related to invasion, asexual replication, and sexual development; and (iv) stage-specific. We observed posttranscriptional gene silencing through translational repression of messenger RNA during sexual development, and a 47-base 3′ untranslated region motif is implicated in this process.
Total citations
Scholar articles
N Hall, M Karras, JD Raine, JM Carlton, TWA Kooij… - Science, 2005