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Accurate estimation of ventricular volumes plays an essential role in clinical diagnosis of cardiac diseases. Existing methods either rely on segmentation or are restricted to direct estimation of the left ventricle. In this paper, we propose a novel method for direct and joint volume estimation of bi-ventricles, i.e., the left and right ventricles, without segmentation and user inputs. Based on the cardiac image representation by multiple and complementary features, we adopt regression forests to jointly estimate the two volumes. Our method is validated on a dataset of 56 subjects with a total of 3360 MR images which shows that our method can achieve a high correlation coefficient of around 0.9 with manual segmentation obtained by human experts. With our proposed method, the most daily-used estimation of cardiac function, e.g., ejection fraction, can be conducted in a much more efficient, accurate and convenient …