Authors
Linda R Peterson, Vanessa Xanthakis, Meredith S Duncan, Stefan Gross, Nele Friedrich, Henry Völzke, Stephan B Felix, Hui Jiang, Rohini Sidhu, Matthias Nauck, Xuntian Jiang, Daniel S Ory, Marcus Dörr, Ramachandran S Vasan, Jean E Schaffer
Publication date
2018/5/3
Journal
Journal of the American Heart Association
Volume
7
Issue
10
Pages
e007931
Description
Background
Recent studies suggest that circulating concentrations of specific ceramide species may be associated with coronary risk and mortality. We sought to determine the relations between the most abundant plasma ceramide species of differing acyl chain lengths and the risk of coronary heart disease (CHD) and mortality in community‐based samples.
Methods and Results
We developed a liquid chromatography/mass spectrometry assay to quantify plasma C24:0, C22:0, and C16:0 ceramides and ratios of these very–long‐chain/long‐chain ceramides in 2642 FHS (Framingham Heart Study) participants and in 3134 SHIP (Study of Health in Pomerania) participants. Over a mean follow‐up of 6 years in FHS, there were 88 CHD and 90 heart failure (HF) events and 239 deaths. Over a median follow‐up time in SHIP of 5.75 years for CHD and HF and 8.24 years for mortality, there were 209 CHD and 146 HF …
Scholar articles
LR Peterson, V Xanthakis, MS Duncan, S Gross… - Journal of the American Heart Association, 2018