Authors
Gotja Schaffrath, Hanna Kische, Stefan Gross, Henri Wallaschofski, Henry Völzke, Marcus Dörr, Matthias Nauck, Brian G Keevil, Georg Brabant, Robin Haring
Publication date
2015/12/1
Journal
Maturitas
Volume
82
Issue
4
Pages
424-430
Publisher
Elsevier
Description
Objectives
The aims of this study were to ascertain whether women with high levels of serum total testosterone (TT) or low levels of sex hormone-binding globulin (SHBG) are more likely to develop cardiovascular disease (CVD), and to investigate potential associations between sex hormones and mortality (all-cause, as well as cause-specific) in the general population.
Study design and main outcome measures
Data on 2129 women with a mean age of 49.0 years were obtained from the population-based Study of Health in Pomerania over a median follow-up of 10.9 years. Associations of baseline levels of TT, SHBG, and rostenedione (ASD), and free testosterone (fT), and of the free androgen index (FAI), with follow-up CVD morbidity, as well as all-cause and CVD mortality, were analyzed using multivariable regression modeling.
Results
At baseline the prevalence rate of CVD was 17.8% (378 women) and the …
Scholar articles
G Schaffrath, H Kische, S Gross, H Wallaschofski… - Maturitas, 2015