Authors
Deanne K Thompson, Stephen J Wood, Lex W Doyle, Simon K Warfield, Gregory A Lodygensky, Peter J Anderson, Gary F Egan, Terrie E Inder
Publication date
2008/5
Journal
Annals of neurology
Volume
63
Issue
5
Pages
642-651
Publisher
Wiley Subscription Services, Inc., A Wiley Company
Description
Objective
To compare preterm (PT) and full‐term (FT) infant hippocampal volumes and to investigate the relations among PT hippocampal volume, perinatal risk factors, and neurodevelopmental outcome.
Methods
A total of 184 PT and 32 full‐term infants underwent magnetic resonance imaging at term equivalent age with manual segmentation of the hippocampi on coronal slices. Perinatal data were collected and 2‐year neurodevelopment was evaluated with the Mental Development Index and Psychomotor Development Index on the Bayley Scales of Infant Development.
Results
PT and FT infant hippocampi did not significantly differ after controlling for head size, and percentage reductions in PT hippocampi (3.4%) were less than for cortical (7%) and deep nuclear gray matter (13%), and total brain tissue volume (4.7%). PT hippocampal volumes were significantly lower in infants with moderate‐to‐severe …
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Scholar articles
DK Thompson, SJ Wood, LW Doyle, SK Warfield… - Annals of neurology, 2008