Authors
Deanne K Thompson, Joseph YM Yang, Jian Chen, Claire E Kelly, Christopher L Adamson, Bonnie Alexander, Courtney Gilchrist, Lillian G Matthews, Katherine J Lee, Rodney W Hunt, Jeanie LY Cheong, Megan Spencer-Smith, Jeffrey J Neil, Marc L Seal, Terrie E Inder, Lex W Doyle, Peter J Anderson
Publication date
2022/3/1
Journal
Neurology
Volume
98
Issue
9
Pages
e924-e937
Publisher
Lippincott Williams & Wilkins
Description
Background and Objectives
To investigate brain regional white matter development in full-term (FT) and very preterm (VP) children at term equivalent and 7 and 13 years of age based on the ratio of T1- and T2-weighted MRI (T1-w/T2-w), including (1) whether longitudinal changes differ between birth groups or sexes, (2) associations with perinatal risk factors in VP children, and (3) relationships with neurodevelopmental outcomes at 13 years.
Methods
Prospective longitudinal cohort study of VP (born <30 weeks' gestation or <1,250 g) and FT infants born between 2001 and 2004 and followed up at term equivalent and 7 and 13 years of age, including MRI studies and neurodevelopmental assessments. T1-w/T2-w images were parcellated into 48 white matter regions of interest.
Results
Of 224 VP participants and 76 FT participants, 197 VP and 55 FT participants had useable T1-w/T2-w data from at least one timepoint …
Total citations
Scholar articles
DK Thompson, JYM Yang, J Chen, CE Kelly… - Neurology, 2022