Authors
K Kavita, F de Mets, S Gottesman
Publication date
2018
Journal
Current Opinion in Microbiology
Volume
42
Pages
53-61
Publisher
ScienceDirect
Description
Highlights
- Novel cross-linking and sequencing methods uncover new sRNAs and sRNA networks.
- Many sRNAs are encoded within the 3′ and 5′ UTRs of mRNA as well as elsewhere.
- sRNA availability can be regulated post-transcriptionally by decoy and sponge RNAs.
- Hfq can regulate mRNA translation without sRNAs, alone and with other proteins.
- Some sRNAs that use Hfq also bind and regulate translational repressor CsrA.
Hfq, an RNA chaperone, promotes the pairing of small RNAs (sRNAs) to target mRNAs, mediating post-transcriptional regulation of mRNA stability and translation. This regulation contributes to bacterial adaptation during stress and pathogenesis. Recent advances in sequencing techniques demonstrate the presence of sRNAs encoded not only in intergenic regions but also from the 3′ and 5′ UTRs of mRNAs, expanding sRNA regulatory networks. Additional layers of regulation by Hfq …
Scholar articles
K Kavita, F de Mets, S Gottesman - Current opinion in microbiology, 2018