Authors
Adish Ezatagha, Anamaria Dascalu, John L Sievenpiper, Elena Jovanovski, Shirin Panahi, Alexandra Jenkins, Vladimir Vuksan
Publication date
2006/3
Source
The FASEB Journal
Volume
20
Issue
4
Pages
A580-A580
Publisher
Federation of American Societies for Experimental Biology
Description
BACKGROUND
Placebo is defined as an inert substance not possessing any biological effect. But this definition may not apply to all placebos. We previously noticed that a cornstarch‐placebo decreased the glycemic response to a 75g‐oral glucose tolerance test (75g‐OGTT) compared with a water‐control. Our objective was to investigate the effect of five common placebos on glycemia.
METHODS
Using a double‐blind, randomized, multiple‐crossover design, 10 healthy subjects (gender:6M:4F, age:33.1±4y, BMI:27.1±1.7kg/m2) received 7 treatments: 9g glucose‐placebo, lactose‐placebo, lactulose‐placebo, wheat‐bran‐placebo, and cornstarch‐placebo and two water controls. Each treatment was given 40‐min before a 75g‐OGTT with blood drawn at −40, 0, 15, 30, 45, 60, 90, and 120‐min.
RESULTS
Two‐way ANOVA showed a significant effect of treatment(p<0.001) and time (p<0.001) on incremental …
Total citations
20081
Scholar articles
A Ezatagha, A Dascalu, JL Sievenpiper, E Jovanovski… - 2006