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DATATOP (Deprenyl and Tocopherol Antlox~ dat~ ve Therapy of Park~ nson~ sm){sa double-bhnd randomized controlled trial for patients w~ th early untreated Parkmson's d~ sease Thirty-four~ nvest~ gators enrolled 800 patients~ na 2X2 factorial design Primary endpo~ nt s the determination by the enrolhng~ nvest~ gator of the need to treat w~ th levodopa. Secondary response variables determined by~ nvest~ gators and/or their coordinators at scheduled follow-up ws~ ts nclude Hoehn and Yahr staging, Schwab-England Activities of Da~ ly L~ v~ ng (ADL) Score, and the Un~ fied Park~ nson's D~ sease Rating Scale, w~ th~ ts mental, motor and ADL components A prehm~ nary analys~ s prompted by the results of~ ndependent monitoring revealed that 176 of 401 subjects not rece~ wng deprenyl had reached endpo~ nt by May 1989, compared w~ th only 97 of the 399 subjects receiving deprenyl (N Engl J Med …