Authors
Didier M Payen, Joelle Guilhot, Yoann Launey, Anne Claire Lukaszewicz, Mahmoud Kaaki, Benoit Veber, Julien Pottecher, Olivier Joannes-Boyau, Laurent Martin-Lefevre, Matthieu Jabaudon, Olivier Mimoz, Rémi Coudroy, Martine Ferrandière, Eric Kipnis, Carlos Vela, Stéphanie Chevallier, Jihad Mallat, René Robert, ABDOMIX Group
Publication date
2015/6
Journal
Intensive care medicine
Volume
41
Pages
975-984
Publisher
Springer Berlin Heidelberg
Description
Purpose
To test whether the polymyxin B hemoperfusion (PMX HP) fiber column reduces mortality and organ failure in peritonitis-induced septic shock (SS) from abdominal infections.
Method
Prospective, multicenter, randomized controlled trial in 18 French intensive care units from October 2010 to March 2013, enrolling 243 patients with SS within 12 h after emergency surgery for peritonitis related to organ perforation. The PMX HP group received conventional therapy plus two sessions of PMX HP. Primary outcome was mortality on day 28; secondary outcomes were mortality on day 90 and a reduction in the severity of organ failures based on Sequential Organ Failure Assessment (SOFA) scores.
Results
Primary outcome: day 28 mortality in the PMX HP group (n = 119) was 27.7 versus 19.5 % in the conventional group …
Scholar articles
DM Payen, J Guilhot, Y Launey, AC Lukaszewicz… - Intensive care medicine, 2015