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Water resources in high mountains play a fundamental role for societies and ecosystems both locally and downstream. Impacts of global change, including climate change, glacier shrinkage, and socioeconomic forces related to demographics, agroindustrial development, and hydroelectricity generation; pose new hydrological risks for human livelihoods. However, these hydroclimatic and socioeconomic drivers of water resource change are often poorly quantified and interconnected, while data scarcity poses challenges in these regions. Here we review the state of knowledge for two major catchments in the Peruvian Andes, which hold the largest tropical glacier mass worldwide: the Santa River (Cordillera Blanca) and Vilcanota River (Cordillera Vilcanota). Our integrative review of water resource change and comparative discharge analysis of two gauging stations in the Santa and Vilcanota River catchments show …