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The evaluation of a bus-based smart myoelectric electrode/amplifier is described that is to be used in conjunction with a multi-function prosthetic hand controller. The smart electrode/amplifier was designed to meet power consumption and size specifications of commercially available myoelectric amplifiers used for prosthetic control applications while providing a number of additional features. This paper investigates the electrode/amplifier requirements for a pattern classifier system and compares them to those currently accepted within a clinical setting. System testing and evaluation was performed with both normally limbed subjects and traumatic amputees.