Authors
RHSR Roxburgh, SR Seaman, T Masterman, AE Hensiek, SJ Sawcer, S Vukusic, I Achiti, C Confavreux, M Coustans, E Le Page, G Edan, GV McDonnell, S Hawkins, M Trojano, M Liguori, Eleonora Cocco, MARIA GIOVANNA Marrosu, F Tesser, MA Leone, A Weber, F Zipp, B Miterski, JT Epplen, A Oturai, P Soelberg Sørensen, EG Celius, N Téllez Lara, X Montalban, P Villoslada, AM Silva, M Marta, I Leite, B Dubois, Jordi Rubio, H Butzkueven, T Kilpatrick, MP Mycko, KW Selmaj, ME Rio, M Sá, G Salemi, G Savettieri, J Hillert, DAS Compston
Publication date
2005/4/12
Journal
Neurology
Volume
64
Issue
7
Pages
1144-1151
Publisher
Lippincott Williams & Wilkins
Description
Background: There is no consensus method for determining progression of disability in patients with multiple sclerosis (MS) when each patient has had only a single assessment in the course of the disease.
Methods: Using data from two large longitudinal databases, the authors tested whether cross-sectional disability assessments are representative of disease severity as a whole. An algorithm, the Multiple Sclerosis Severity Score (MSSS), which relates scores on the Expanded Disability Status Scale (EDSS) to the distribution of disability in patients with comparable disease durations, was devised and then applied to a collection of 9,892 patients from 11 countries to create the Global MSSS. In order to compare different methods of detecting such effects the authors simulated the effects of a genetic factor on disability.
Results: Cross-sectional EDSS measurements made after the first year were …
Total citations
Scholar articles
R Roxburgh, SR Seaman, T Masterman, AE Hensiek… - Neurology, 2005