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Gambling is a specific type of economic activity that significantly affects many aspects of society. It is associated mainly with negative impacts on the lives of individuals and their families, but it also has a positive economic impact on the public budgets of states, regions and municipalities. In this article, we focus on a geographic assessment of the development of gambling in the Czech Republic, which is based on a spatial analysis of data on licensed games and data on the revenues of municipalities arising from gambling. It turns out that the occurrence of gambling is strongly influenced by binary centre/periphery dichotomy, with the exception of the Czech-Austrian and Czech-German border areas which are characterised by a high concentration of casinos resulting from more rigid regulation of gambling on the other side of the border. In this research, the authors develop an innovative scientific discipline within Czech human geography: The geography of gambling.