Authors
Maia Kayal, Michael Plietz, Marlana Radcliffe, Anam Rizvi, Clara Yzet, Emily Tixier, Robert P Hirten, Benjamin Cohen, Patricia Sylla, Sergey Khaitov, Alexander Greenstein, Jean‐Frederic Colombel, Marla C Dubinsky, Ryan C Ungaro
Publication date
2019/12
Journal
Alimentary pharmacology & therapeutics
Volume
50
Issue
11-12
Pages
1189-1194
Description
Background
The significance of endoscopic activity in asymptomatic ulcerative colitis (UC) patients with an ileal pouch is unknown.
Aim
To investigate the association of endoscopic pouch activity in asymptomatic patients with the subsequent development of pouchitis.
Methods
We analyzed a retrospective cohort of patients with UC or IBD‐unspecified who underwent a total proctocolectomy with ileal pouch anal anastomosis (IPAA). Asymptomatic patients with a Pouchitis Disease Activity Index (PDAI) symptom sub‐score of zero who underwent an index surveillance pouchoscopy were included. Endoscopic pouch body activity was graded as 0: normal, 1: mucosal inflammation, or 2: mucosal breaks (ulcers and/or erosions). The primary outcome was primary acute idiopathic pouchitis defined as PDAI score ≥ 7 with symptoms lasting less than four weeks and responsive to standard antibiotics, not otherwise …
Scholar articles
M Kayal, M Plietz, M Radcliffe, A Rizvi, C Yzet, E Tixier… - Alimentary pharmacology & therapeutics, 2019