View article

Methods

This was a single center, retrospective study of patients 18 years of age or older with medically refractory UC who underwent TPC with IPAA complicated by CPI on biologic therapy. CPI included chronic pouchitis and CDL pouch inflammation, definitions are provided in Supplementary Material. The primary outcome of clinical remission was assessed by physician global assessment and incorporated improvement in symptoms (frequency, urgency, hematochezia, abdominal or pelvic pain), endoscopy when available (ulcerations), and laboratory indices when available (C-reactive protein, erythrocyte sedimentation rate) assessed at 12 months after biologic initiation. Secondary outcomes included endoscopic improvement of pouch ulceration by 12 months after biologic initiation and pouch failure at any time during follow-up. Description of statistical analysis is provided in Supplementary Material.

Results

A …