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This paper develops a theoretical framework based on empirical case study research that explains the role of tacit knowledge in technical change and how scientific knowledge is used in innovation. It develops a theoretical argument that proposes that science cannot be directly applied to produce technology because science answers the wrong question. Innovation starts with a desired end result and attempts to find the unknown starting conditions that will achieve it. Scientific knowledge, by contrast, goes in the opposite direction, from known starting conditions to unknown end results. This difference in direction is overcome by following tacitly understood traditions of technological knowledge that co-evolve with technological paradigms, but are themselves outside the realm of science. The paper demonstrates how technologies are `constructed socially' and embody sociological and political conceptions of …