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Objective: Assess if preoperative Ca125 levels can predict stage & likelihood of debulking in ovarian cancer. Methods: Ca125 assessed in 591 patients with ovarian cancers managed in Sheffield.

Results:(Table1) Ca125 was raised (. 35IU) in: 85% of all ovarian cancers; 89% of epithelial ovarian cancers (EOC); 100% of primary peritoneal tumours (PPT); 60% of borderline tumours. Ca125 levels increased from FIGO stage I to IV and were significantly higher in stage III/IV compared to stage I, and in patients with residual disease compared to those with no residual disease post-operatively (p= 0.02 Independent sample t-test). No significant difference in Ca125 was seen between optimally or sub-optimally debulked patients. Receiver operator curves (ROC) curves using Ca125 as adiagnostic predictor, show good separation of stage I from stage II/III/IV disease and of patients with no residual disease from those with …