Authors
Jussi M Tikkanen, Marcelo Cypel, Tiago N Machuca, Sassan Azad, Matthew Binnie, Chung-Wai Chow, Cecilia Chaparro, Michael Hutcheon, Kazuhiro Yasufuku, Marc de Perrot, Andrew F Pierre, Thomas K Waddell, Shaf Keshavjee, Lianne G Singer
Publication date
2015/4/1
Journal
The Journal of heart and lung transplantation
Volume
34
Issue
4
Pages
547-556
Publisher
Elsevier
Description
Background
Ex vivo lung perfusion (EVLP) is an effective method to assess and improve the function of otherwise unacceptable lungs, alleviating the shortage of donor lungs. The early results with EVLP have been encouraging, but longer-term results, including functional and patient-reported outcomes, are not well characterized.
Methods
This retrospective single-center study included all lung transplants performed between September 2008 and December 2012. We investigated whether survival or rate of chronic lung allograft dysfunction (CLAD) differed in recipients of EVLP-treated lungs compared with contemporaneous recipients of conventional donor lungs. We also studied functional (highest forced expiratory volume in 1 second predicted, change in 6-minute walk distance, number of acute rejection episodes) and quality of life outcomes.
Results
Of 403 lung transplants that were performed, 63 patients (15.6 …
Scholar articles
JM Tikkanen, M Cypel, TN Machuca, S Azad, M Binnie… - The Journal of heart and lung transplantation, 2015