Authors
Jussi M Tikkanen, Lianne G Singer, S Joseph Kim, Yanhong Li, Matthew Binnie, Cecilia Chaparro, Chung-Wai Chow, Tereza Martinu, Sassan Azad, Shaf Keshavjee, Kathryn Tinckam
Publication date
2016/9/1
Journal
American journal of respiratory and critical care medicine
Volume
194
Issue
5
Pages
596-606
Publisher
American Thoracic Society
Description
Rationale: Despite increasing evidence about the role of donor-specific human leukocyte antigen (HLA) antibodies in transplant outcomes, the incidence and impact of de novo donor-specific antibodies (dnDSA) after lung transplantation remains unclear.
Objectives: To describe the incidence, characteristics, and impact of dnDSA after lung transplantation.
Methods: We investigated a single-center cohort of 340 lung transplant recipients undergoing transplant during 2008 to 2011. All patients underwent HLA-antibody testing quarterly pretransplant and at regular intervals over the first 24 months after transplant. The patients received modified immunosuppression depending on their pretransplant sensitization status. Risk factors for dnDSA development, as well as the associations of dnDSA with patient survival and chronic lung allograft dysfunction (CLAD), were determined using multivariable analysis.
Measurements …
Scholar articles
JM Tikkanen, LG Singer, SJ Kim, Y Li, M Binnie… - American journal of respiratory and critical care …, 2016