Authors
Tim Vanuytsel, Sander Van Wanrooy, Hanne Vanheel, Christophe Vanormelingen, Sofie Verschueren, Els Houben, Shadea Salim Rasoel, Joran Tόth, Lieselot Holvoet, Ricard Farré, Lukas Van Oudenhove, Guy Boeckxstaens, Kristin Verbeke, Jan Tack
Publication date
2014/8/1
Journal
Gut
Volume
63
Issue
8
Pages
1293-1299
Publisher
BMJ Publishing Group
Description
Objective
Intestinal permeability and psychological stress have been implicated in the pathophysiology of IBD and IBS. Studies in animals suggest that stress increases permeability via corticotropin-releasing hormone (CRH)-mediated mast cell activation. Our aim was to investigate the effect of stress on intestinal permeability in humans and its underlying mechanisms.
Design
Small intestinal permeability was quantified by a 2 h lactulose–mannitol urinary excretion test. In a first study, 23 healthy volunteers were subjected to four different conditions: control; indomethacin; public speech and anticipation of electroshocks. In a second study, five test conditions were investigated in 13 volunteers: control; after pretreatment with disodium cromoglycate (DSCG); administration of CRH; DSCG+CRH and DSCG+public speech.
Results
Indomethacin, as a positive comparator (0.071±0.040 vs 0.030±0.022; p<0.0001), and …
Scholar articles
T Vanuytsel, S Van Wanrooy, H Vanheel… - Gut, 2014