Authors
Raghavan Murugan, Xiaoyan Wen, Nilesh Shah, Minjae Lee, Lan Kong, Francis Pike, Christopher Keener, Mark Unruh, Kevin Finkel, Anitha Vijayan, Paul M Palevsky, Emil Paganini, Melinda Carter, Michele Elder, John A Kellum
Publication date
2014/10/1
Journal
Nephrology Dialysis Transplantation
Volume
29
Issue
10
Pages
1854-1864
Publisher
Oxford University Press
Description
Background
Survivors of critical illness complicated by acute kidney injury requiring renal replacement therapy (RRT) are at an increased risk of dialysis dependence and death but the mechanisms are unknown.
Methods
In a multicenter, prospective, cohort study of 817 critically ill patients receiving RRT, we examined association between Day 1 plasma inflammatory [interleukin (IL)-1β, IL-6, IL-8, IL-10 and IL-18; macrophage migration inhibitory factor (MIF) and tumor necrosis factor]; apoptosis [tumor necrosis factor receptor (TNFR)-I and TNFR-II and death receptor (DR)-5]; and growth factor (granulocyte macrophage colony stimulating factor) biomarkers and renal recovery and mortality at Day 60. Renal recovery was defined as alive and RRT independent.
Results
Of 817 participants, 36.5% were RRT independent and 50.8% died. After adjusting for …
Scholar articles
R Murugan, X Wen, N Shah, M Lee, L Kong, F Pike… - Nephrology Dialysis Transplantation, 2014