Authors
Yuri T Utsunomiya, Adriana S Do Carmo, Roberto Carvalheiro, Haroldo HR Neves, Márcia C Matos, Ludmilla B Zavarez, Ana M Pérez O’Brien, Johann Sölkner, John C McEwan, John B Cole, Curtis P Van Tassell, Flávio S Schenkel, Marcos VGB Da Silva, Laercio R Porto Neto, Tad S Sonstegard, José F Garcia
Publication date
2013/12
Journal
BMC genetics
Volume
14
Pages
1-12
Publisher
BioMed Central
Description
Background
Birth weight (BW) is an economically important trait in beef cattle, and is associated with growth- and stature-related traits and calving difficulty. One region of the cattle genome, located on Bos primigenius taurus chromosome 14 (BTA14), has been previously shown to be associated with stature by multiple independent studies, and contains orthologous genes affecting human height. A genome-wide association study (GWAS) for BW in Brazilian Nellore cattle (Bos primigenius indicus) was performed using estimated breeding values (EBVs) of 654 progeny-tested bulls genotyped for over 777,000 single nucleotide polymorphisms (SNPs).
Results
The most significant SNP (rs133012258, PGC = 1.34 × 10-9), located at BTA14:25376827, explained 4.62% of the variance in BW EBVs. The surrounding 1 Mb region presented high identity with …
Total citations
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Scholar articles
YT Utsunomiya, AS Do Carmo, R Carvalheiro… - BMC genetics, 2013