Authors
Elisa Peripolli, Nedenia Bonvino Stafuzza, Danísio Prado Munari, André Luís Ferreira Lima, Renato Irgang, Marco Antonio Machado, João Cláudio do Carmo Panetto, Ricardo Vieira Ventura, Fernando Baldi, Marcos Vinícius Gualberto Barbosa da Silva
Publication date
2018/12
Journal
BMC genomics
Volume
19
Pages
1-13
Publisher
BioMed Central
Description
Background
Runs of homozygosity (ROH) are continuous homozygous segments of the DNA sequence. They have been applied to quantify individual autozygosity and used as a potential inbreeding measure in livestock species. The aim of the present study was (i) to investigate genome-wide autozygosity to identify and characterize ROH patterns in Gyr dairy cattle genome; (ii) identify ROH islands for gene content and enrichment in segments shared by more than 50% of the samples, and (iii) compare estimates of molecular inbreeding calculated from ROH (FROH), genomic relationship matrix approach (FGRM) and based on the observed versus expected number of homozygous genotypes (FHOM), and from pedigree-based coefficient (FPED).
Results
ROH were identified in all animals, with an average number of 55.12 ± 10.37 segments and a …
Scholar articles
E Peripolli, NB Stafuzza, DP Munari, ALF Lima… - BMC genomics, 2018