Authors
Oana M Cociorva, Bei Li, Tyzoon Nomanbhoy, Qiang Li, Ayako Nakamura, Kai Nakamura, Masahiro Nomura, Kyoko Okada, Shigeki Seto, Kazuhiro Yumoto, Marek Liyanage, Melissa C Zhang, Arwin Aban, Brandon Leen, Anna Katrin Szardenings, Jonathan S Rosenblum, John W Kozarich, Yasushi Kohno, Kevin R Shreder
Publication date
2011/10/1
Journal
Bioorganic & medicinal chemistry letters
Volume
21
Issue
19
Pages
5948-5951
Publisher
Pergamon
Description
The synthesis, GSK-3β inhibitory activity, and anti-microbial activity of bicyclic and tricyclic derivatives of the 5,7-diamino-6-fluoro-4-quinolone-3-carboxylic acid scaffold were studied. Kinase selectivity profiling indicated that members of this class were potent and highly selective GSK-3 inhibitors.
Scholar articles
OM Cociorva, B Li, T Nomanbhoy, Q Li, A Nakamura… - Bioorganic & medicinal chemistry letters, 2011