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Extracting information from brain signals in advanced Brain Machine Interfaces (BMI) often requires computationally demanding processing. The complexity of the algorithms traditionally employed to process multi-channel neural data, such as Principal Component Analysis (PCA), dramatically increases while scaling-up the number of channels and requires more power-hungry computational platforms. This could hinder the development of low-cost and low-power interfaces which can be used in wearable or implantable real-time systems. This work proposes a new algorithm for the detection of epileptic seizure based on compressively sensed EEG information, and its optimization on a low-power multi-core SoC for near-sensor data analytics: Mr. Wolf. With respect to traditional algorithms based on PCA, the proposed approach reduces the computational complexity by 4.4× in ARM Cortex M4-based MCU …