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The meshless local radial basis function-based differential quadrature (RBF-DQ) method is applied on two-dimensional heat conduction for different irregular geometries. This method is the combination of differential quadrature approximation of derivatives and function approximation of radial basis function. Four different geometries with regular and irregular boundaries are considered, and numerical results are compared with those gained by finite element (FE) solution achieved by COMSOL commercial code. Outcomes prove that current technique is in very good agreement with FEM and this fact that RBF-DQ method is an accurate and flexible method in solution of heat conduction problems.