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A methodology to design energy-efficient timetables in Rapid Railway Transit Networks is presented. Using an empirical description of the train energy consumption as a function of running times, the timetable design problem is modelled as a Mixed Integer Non-Linear optimization problem (MINLP) for a complete two-way line. In doing so, all the services in both directions along a certain planning horizon are considered while attending a known passengers’ demand. The MINLP formulation, which depends on train loads, is fully linearised supposing train loads are fixed. A sequential Mixed Integer Linear solving procedure is then used to solve the timetabling optimization problem with unknown train loads. The proposed methodology emphasizes the need of considering all the services running during the planning horizon when designing energy-efficient timetables, as consequence of the relationship among train …