View article

Idiopathic pulmonary fibrosis (IPF), the most common form of interstitial lung disease (ILD), is characterized by progressive and irreversible scarring. Interstitial lung abnormalities (ILA), which can precede ILD, are common in relatives of patients with IPF and familial pulmonary fibrosis but screening relatives of patients with non-IPF ILD is not routine. We aimed to determine the prevalence of ILA’s in family members of patients with fibrotic ILD, regardless of fibrotic pattern. We conducted a cross-sectional analysis of first-degree relatives of probands with fibrotic lung disease. Proband diagnosis was ascertained using physician records. Participants underwent a high-resolution computed tomography (HRCT). ILAs, defined as non-dependent ground glass, reticulations, non-emphysematous cysts, traction bronchiectasis or honeycombing affecting> 5% of any lung zone, were determined by …