Authors
Claire F McGroder, Spencer Hansen, Karen Hinckley Stukovsky, David Zhang, P Hrudaya Nath, Mary M Salvatore, Sushilkumar K Sonavane, Nina Terry, Justin T Stowell, Belinda M D'Souza, Jay S Leb, Shifali Dumeer, Muhammad U Aziz, Kiran Batra, Eric A Hoffman, Elana J Bernstein, John S Kim, Anna J Podolanczuk, Jerome I Rotter, Ani W Manichaikul, Stephen S Rich, David J Lederer, R Graham Barr, Robyn L McClelland, Christine Kim Garcia
Publication date
2023/6/1
Journal
European Respiratory Journal
Volume
61
Issue
6
Publisher
European Respiratory Society
Description
Background
The incidence of newly developed interstitial lung abnormalities (ILA) and fibrotic ILA has not been previously reported.
Methods
Trained thoracic radiologists evaluated 13 944 cardiac computed tomography scans for the presence of ILA in 6197 Multi-Ethnic Study of Atherosclerosis (MESA) longitudinal cohort study participants >45 years of age from 2000 to 2012. Five percent of the scans were re-read by the same or a different observer in a blinded fashion. After exclusion of participants with ILA at baseline, incidence rates and incidence rate ratios for ILA and fibrotic ILA were calculated.
Results
The intra-reader agreement of ILA was 92.0% (Gwet's AC1 0.912, intraclass correlation coefficient (ICC) 0.982) and the inter-reader agreement of ILA was 83.5% (Gwet's AC1 0.814, ICC 0.969). Incidence of ILA and fibrotic ILA was estimated to be 13.1 and 3.5 cases per 1000 person-years, respectively. In …
Total citations
Scholar articles
CF McGroder, S Hansen, KH Stukovsky, D Zhang… - European Respiratory Journal, 2023