Authors
Arely Cruz-Sanchez, Shadini Dematagoda, Ridda Ahmed, Sakhithya Mohanathaas, Nicole Odenwald, Maithe Arruda-Carvalho
Publication date
2020/6/30
Journal
Scientific reports
Volume
10
Issue
1
Pages
10612
Publisher
Nature Publishing Group UK
Description
Spontaneous recognition memory tasks build on an animal’s natural preference for novelty to assess the what, where and when components of episodic memory. Their simplicity, ethological relevance and cross-species adaptability make them extremely useful to study the physiology and pathology of memory. Recognition memory deficits are common in rodent models of neurodevelopmental disorders, and yet very little is known about the expression of spontaneous recognition memory in young rodents. This is exacerbated by the paucity of data on the developmental onset of recognition memory in mice, a major animal model of disease. To address this, we characterized the ontogeny of three types of spontaneous recognition memory in mice: object location, novel object recognition and temporal order recognition. We found that object location is the first to emerge, at postnatal day (P)21. This was followed by …
Total citations
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