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Aim of the present research is the setup of an alternative methodology and instrumentation to be applied for cleaning ancient tapestries which need restoration. A new instrument based on the simultaneous dispensing and aspiration of water (hydro-aspiration method) and capable of removing the deposited particulate matter (DPM), has been developed and its performances tested on an ancient polymateric tapestry belonging a precious series called “Ulysses Stories”, stored at the Quirinale Palace (Rome). This innovative system has been compared to traditional methodologies commonly employed by restores for tapestries cleaning operations. At this purpose, the quantity and the chemical composition of the particulate matter removed by the different systems and collected on quartz fibre filters, have been estimated. Different analytical techniques have been applied to this purpose. The hydro-aspiration method resulted to be more efficient in removing the dirt and also in preserving the structure of these precious metallic yarns.