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In this paper, we investigate secure transmission over the large-scale multiple-antenna wiretap channel with finite alphabet inputs. First, we investigate the case where instantaneous channel state information (CSI) of the eavesdropper is known at the transmitter. We show analytically that a generalized singular value decomposition (GSVD)-based design, which is optimal for Gaussian inputs, may exhibit a severe performance loss for finite alphabet inputs in the high signal-to-noise ratio regime. In light of this, we propose a novel Per-Group-GSVD (PG-GSVD) design, which can effectively compensate the performance loss caused by the GSVD design. More importantly, the computational complexity of the PG-GSVD design is by orders of magnitude lower than that of the existing design for finite alphabet inputs while the resulting performance loss is minimal. Then, we extend the PG-GSVD design to the case where …