Authors
Jeffrey R Binder, Stephen M Rao, Thomas A Hammeke, Julie A Frost, Peter A Bandettini, Andrzej Jesmanowicz, James S Hyde
Publication date
1995/6/1
Journal
Archives of Neurology
Volume
52
Issue
6
Pages
593-601
Publisher
American Medical Association
Description
Objective
To develop a procedure for noninvasive measurement of language lateralization with functional magnetic resonance imaging (MRI).
Design
Functional neuroimaging using time-series echo-planar MRI.
Setting
University medical center research facility.
Subjects
Five healthy, right-handed, young adults.
Main Outcome Measures
Number of MRI voxels in left and right hemispheres showing task-related signal increases during two contrasting auditory processing tasks. The nonlinguistic task involved processing of pure tones, while the linguistic task involved processing of single words based on semantic content.
Results
The pure-tone processing task activated temporal lobe auditory areas and dorsolateral frontal regions bilaterally. Using this task as a control condition, the semantic processing task resulted in lateralized activity in distributed regions of the left hemisphere. A significant effect of task on …
Total citations
Scholar articles
JR Binder, SM Rao, TA Hammeke, JA Frost… - Archives of Neurology, 1995