Authors
Mark Montebello, Meryem Jefferies, Llewellyn Mills, Raimondo Bruno, Jan Copeland, Iain McGregor, Consuelo Rivas, Melissa A Jackson, Catherine Silsbury, Adrian Dunlop, Nicholas Lintzeris, Agonist Replacement For Cannabis Dependence Study Group
Publication date
2022/5/1
Journal
Drug and Alcohol Dependence
Volume
234
Pages
109388
Publisher
Elsevier
Description
Background
Mood, sleep and pain problems are common comorbidities among treatment-seeking cannabis-dependent patients. There is limited evidence suggesting treatment for cannabis dependence is associated with their improvement. This study explored the impact of cannabis dependence treatment on these comorbidities.
Methods
This is a secondary analysis from a 12-week double-blind placebo-controlled trial testing the efficacy of a cannabis agonist (nabiximols) against placebo in reducing illicit cannabis use in 128 cannabis-dependent participants. Outcome measurements including DASS-21 (Depression, Anxiety, and Stress subscales); Insomnia Severity Index (ISI); and Brief Pain Inventory (BPI), were performed at weeks 0, 4, 8, 12 and 24. Each was analysed as continuous outcomes and as binary cases based on validated clinical cut-offs.
Results
Among those whose DASS and ISI scores were in the …
Total citations
20221
Scholar articles
M Montebello, M Jefferies, L Mills, R Bruno, J Copeland… - Drug and Alcohol Dependence, 2022