Authors
Suetonia C Palmer, Britta Tendal, Reem A Mustafa, Per Olav Vandvik, Sheyu Li, Qiukui Hao, David Tunnicliffe, Marinella Ruospo, Patrizia Natale, Valeria Saglimbene, Antonio Nicolucci, David W Johnson, Marcello Tonelli, Maria Chiara Rossi, Sunil V Badve, Yeoungjee Cho, Annie-Claire Nadeau-Fredette, Michael Burke, Labib I Faruque, Anita Lloyd, Nasreen Ahmad, Yuanchen Liu, Sophanny Tiv, Tanya Millard, Lucia Gagliardi, Nithin Kolanu, Rahul D Barmanray, Rita McMorrow, Ana Karina Raygoza Cortez, Heath White, Xiangyang Chen, Xu Zhou, Jiali Liu, Andrea Flores Rodríguez, Alejandro Díaz González-Colmenero, Yang Wang, Ling Li, Surya Sutanto, Ricardo Cesar Solis, Fernando Díaz González-Colmenero, René Rodriguez-Gutierrez, Michael Walsh, Gordon Guyatt, Giovanni FM Strippoli
Publication date
2021/1/13
Source
Bmj
Volume
372
Publisher
British Medical Journal Publishing Group
Description
Objective
To evaluate sodium-glucose cotransporter-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists in patients with type 2 diabetes at varying cardiovascular and renal risk.
Design
Network meta-analysis.
Data sources
Medline, Embase, and Cochrane CENTRAL up to 11 August 2020.
Eligibility criteria for selecting studies
Randomised controlled trials comparing SGLT-2 inhibitors or GLP-1 receptor agonists with placebo, standard care, or other glucose lowering treatment in adults with type 2 diabetes with follow up of 24 weeks or longer. Studies were screened independently by two reviewers for eligibility, extracted data, and assessed risk of bias.
Main outcome measures
Frequentist random effects network meta-analysis was carried out and GRADE (grading of recommendations assessment, development, and evaluation) used to assess evidence certainty. Results included estimated …
Total citations
Scholar articles
SC Palmer, B Tendal, RA Mustafa, PO Vandvik, S Li… - Bmj, 2021