Authors
Rachel Kleinloog, Emine Korkmaz, Jaco JM Zwanenburg, Hugo J Kuijf, Fredy Visser, Roos Blankena, Jan A Post, Ynte M Ruigrok, Peter R Luijten, Luca Regli, Gabriel JE Rinkel, Bon H Verweij
Publication date
2014/12/1
Journal
Neurosurgery
Volume
75
Issue
6
Pages
614-622
Publisher
LWW
Description
BACKGROUND:
Risk prediction of rupture of intracranial aneurysms is poor and is based mainly on lumen characteristics. However, characteristics of the aneurysm wall may be more informative predictors. The limited resolution of currently available imaging techniques and the thin aneurysm wall make imaging of wall thickness challenging.
OBJECTIVE:
To introduce a novel protocol for imaging wall thickness variation using ultra--high-resolution 7.0-Tesla (7.0-T) magnetic resonance imaging (MRI).
METHODS:
We studied 33 unruptured intracranial aneurysms in 24 patients with a T1-weighted 3-dimensional magnetization-prepared inversion-recovery turbo-spin-echo whole-brain sequence with a resolution of 0.8× 0.8× 0.8 mm. We performed a validation study with a wedge phantom and with 2 aneurysm wall biopsies obtained during aneurysm treatment using ex vivo MRI and histological examination and …
Scholar articles
R Kleinloog, E Korkmaz, JJM Zwanenburg, HJ Kuijf… - Neurosurgery, 2014