Authors
Laura EM Wisse, Hugo J Kuijf, Anita M Honingh, Hongzhi Wang, John B Pluta, Sandhitsu R Das, David A Wolk, Jaco JM Zwanenburg, Paul A Yushkevich, Mirjam I Geerlings
Publication date
2016/6/1
Journal
American Journal of Neuroradiology
Volume
37
Issue
6
Pages
1050-1057
Publisher
American Journal of Neuroradiology
Description
BACKGROUND AND PURPOSE
High resolution 7T MRI is increasingly used to investigate hippocampal subfields in vivo, but most studies rely on manual segmentation which is labor intensive. We aimed to evaluate an automated technique to segment hippocampal subfields and the entorhinal cortex at 7T MRI.
MATERIALS AND METHODS
The cornu ammonis (CA)1, CA2, CA3, dentate gyrus, subiculum, and entorhinal cortex were manually segmented, covering most of the long axis of the hippocampus on 0.70-mm3 T2-weighted 7T images of 26 participants (59 ± 9 years, 46% men). The automated segmentation of hippocampal subfields approach was applied and evaluated by using leave-one-out cross-validation.
RESULTS
Comparison of automated segmentations with corresponding manual segmentations yielded a Dice similarity coefficient of >0.75 for CA1, the dentate gyrus, subiculum, and entorhinal cortex …
Scholar articles
LEM Wisse, HJ Kuijf, AM Honingh, H Wang, JB Pluta… - American Journal of Neuroradiology, 2016