Authors
Laura EM Wisse, Geert Jan Biessels, Sophie M Heringa, Hugo J Kuijf, Peter R Luijten, Mirjam I Geerlings, Utrecht Vascular Cognitive Impairment VCI Study Group
Publication date
2014/9/1
Journal
Neurobiology of aging
Volume
35
Issue
9
Pages
2039-2045
Publisher
Elsevier
Description
We compared hippocampal subfield and entorhinal cortex (ERC) volumes between patients with mild cognitive impairment (MCI), Alzheimer's disease (AD), and controls without cognitive impairment. Additionally, we investigated the relation between age and hippocampal subfields and ERC in controls. We performed ultra-high field 0.7 mm3 7Tesla magnetic resonance imaging in 16 patients with amnestic MCI, 9 with AD, and 29 controls. ERC, subiculum, cornu ammonis (CA)1, CA2, CA3, and dentate gyrus (DG)&CA4 were traced on T2-weighted images. Analyses of covariance, adjusted for age, sex, and intracranial volume showed that compared with controls and patients with MCI, patients with AD had significantly smaller ERC, subiculum, CA1, CA3, and DG&CA4 volumes. Trend analyses revealed similar associations between ERC and hippocampal subfields and diagnostic group. Older age was significantly …
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