Authors
Nick A Weaver, Hugo J Kuijf, Hugo P Aben, Jill Abrigo, Hee-Joon Bae, Mélanie Barbay, Jonathan G Best, Régis Bordet, Francesca M Chappell, Christopher PLH Chen, Thibaut Dondaine, Ruben S van Der Giessen, Olivier Godefroy, Bibek Gyanwali, Olivia KL Hamilton, Saima Hilal, Irene MC Huenges Wajer, Yeonwook Kang, L Jaap Kappelle, Beom Joon Kim, Sebastian Köhler, Paul LM De Kort, Peter J Koudstaal, Gregory Kuchcinski, Bonnie YK Lam, Byung-Chul Lee, Keon-Joo Lee, Jae-Sung Lim, Renaud Lopes, Stephen DJ Makin, Anne-Marie Mendyk, Vincent CT Mok, Mi Sun Oh, Robert J Van Oostenbrugge, Martine Roussel, Lin Shi, Julie Staals, Maria del C Valdés-Hernández, Narayanaswamy Venketasubramanian, Frans RJ Verhey, Joanna M Wardlaw, David J Werring, Xu Xin, Kyung-Ho Yu, Martine JE Van Zandvoort, Lei Zhao, J Matthijs Biesbroek, Geert Jan Biessels
Publication date
2021/6/1
Journal
The Lancet Neurology
Volume
20
Issue
6
Pages
448-459
Publisher
Elsevier
Description
Background
Post-stroke cognitive impairment (PSCI) occurs in approximately half of people in the first year after stroke. Infarct location is a potential determinant of PSCI, but a comprehensive map of strategic infarct locations predictive of PSCI is unavailable. We aimed to identify infarct locations most strongly predictive of PSCI after acute ischaemic stroke and use this information to develop a prediction model.
Methods
In this large-scale multicohort lesion-symptom mapping study, we pooled and harmonised individual patient data from 12 cohorts through the Meta-analyses on Strategic Lesion Locations for Vascular Cognitive Impairment using Lesion-Symptom Mapping (Meta VCI Map) consortium. The identified cohorts (as of Jan 1, 2019) comprised patients with acute symptomatic infarcts on CT or MRI (with available infarct segmentations) and a cognitive assessment up to 15 months after acute ischaemic stroke …
Total citations
Scholar articles
NA Weaver, HJ Kuijf, HP Aben, J Abrigo, HJ Bae… - The Lancet Neurology, 2021