View article

Preterm delivery accounts for 5% of all deliveries and its consequences contribute to significant individual, medical, and social problems. The neuroanatomical substrates of these disorders are not known, but are essential for understanding mechanisms of causation, and developing strategies for intervention. In the recent years, multivariate pattern recognition methods that analyse all voxels simultaneously have been proposed to characterise the neuroanatomical differences between a reference group of magnetic resonance (MR) images and the population under investigation. Most of these techniques have overcome the difficulty of dealing with the inherent high dimensionality of 3D MR brain image data by using pre-processed segmented images or a small number of specific features. However, an intuitive way of mapping the classification results back into the original image domain for further interpretation …