Authors
Michelle W Voss, Susie Heo, Ruchika S Prakash, Kirk I Erickson, Heloisa Alves, Laura Chaddock, Amanda N Szabo, Emily L Mailey, Thomas R Wójcicki, Siobhan M White, Neha Gothe, Edward McAuley, Bradley P Sutton, Arthur F Kramer
Publication date
2013/11
Journal
Human brain mapping
Volume
34
Issue
11
Pages
2972-2985
Description
Cerebral white matter (WM) degeneration occurs with increasing age and is associated with declining cognitive function. Research has shown that cardiorespiratory fitness and exercise are effective as protective, even restorative, agents against cognitive and neurobiological impairments in older adults. In this study, we investigated whether the beneficial impact of aerobic fitness would extend to WM integrity in the context of a one‐year exercise intervention. Further, we examined the pattern of diffusivity changes to better understand the underlying biological mechanisms. Finally, we assessed whether training‐induced changes in WM integrity would be associated with improvements in cognitive performance independent of aerobic fitness gains. Results showed that aerobic fitness training did not affect group‐level change in WM integrity, executive function, or short‐term memory, but that greater aerobic fitness …
Total citations
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